The science behind icoone®
Roboderm®, the microvacuole model and 15+ published studies
icoone® is built on one idea: the tissue under the skin is a living network of microvacuoles, and it responds better to thousands of small, independent stimulations than to one large fold. This page collects the anatomy, the technology, the scientific committee and every paper — with the manufacturer’s documentation hosted here so you can do your due diligence without leaving the site.
- 15+ published studies
- 40+ scientific committee
- 21,600 micro-stimulations a minute
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The model
Why many small stimulations instead of one big one
1 · Anatomy
The microvacuole
Prof. Jean-Claude Guimberteau’s in-vivo filming showed the subcutaneous tissue as a continuous, sliding network of tiny polyhedral vacuoles — not layers. Stimulation that respects that structure is gentle and distributed.
2 · Technology
Roboderm® Multi Micro Alveolar Stimulation
The patented roller has hundreds of independent micro-stimulators. As it rolls, each one lifts and releases a micro-area — up to 21,600 stimulations a minute, covering 86% of the skin surface, in two hands at once.
3 · Evaluation
A scientific committee, not a marketing claim
40+ physicians, surgeons, physiotherapists and researchers evaluate the programmes; their papers and three scientific-meeting proceedings are listed below.
Figures reported by i-Tech Industries clinical evaluations. Individual results vary.
Hosted here
The documentation library
Manufacturer material supplied to DNA Distribution and hosted on this site. Open any document in a new tab.
- PDFicoone® — The science of skin (manufacturer brochure)Roboderm®, Multi Micro Alveolar Stimulation, the face and body menus
- PDFicoone® Results Book — documented before & after casesManufacturer case photography with session counts
- PDFicoone® Beauty protocol cardsProgram-by-program protocol cards for the aesthetic menu
- PDFicoone® Microfacial brochureThree technologies, 8 actions, 17 handpieces
- PDFicoone® Complete Range — DNA Distribution deckConfigurations, pricing and the U.S. program
- PDFicoone® Microfacial Launch — DNA Distribution deckThe Founders’ 25 U.S. launch
Medical programme documentation (physiotherapy, surgical and other clinical settings) is on the icoone® Medical page.
Published studies
Every paper, with what it covers
Published by i-Tech Industries and its clinical collaborators. Sources open on icoone.com, the manufacturer’s archive, in a new tab.
- 01The sliding mechanics of the subcutaneous structures in man — illustration of a functional unit: the microvacuolesProf. Jean-Claude GuimberteauThe anatomical model behind icoone®: the subcutaneous tissue as a network of microvacuoles that slide and adapt, filmed in vivo — the reason the roller stimulates many small points rather than one fold.Source (PDF) ↗
- 02Micro Multi Alveolar Stimulation in mechanised connective tissue massage according to the theory of the microvacuoleProf. Maullu, Prof. ScuderiHow mechanised connective-tissue massage was re-designed around the microvacuole model, and what changes in the tissue response when stimulation is multi-alveolar.Source (PDF) ↗
- 03Randomised clinical trial on patients’ compliance and the ergonomics of two devices for mechanized massageProf. ScuderiA randomised comparison of patient compliance and ergonomics between two mechanised-massage devices.Source (PDF) ↗
- 04A new technology for connective tissue micro alveolar stimulation: icoone®-HProf. PalmieriTechnology description and evaluations of icoone®-H and the multi micro alveolar stimulation approach.Source (PDF) ↗
- 05Stroma and its cosmetic functional reactivation — Multi Micro Alveolar Stimulation, a revolution in evolutionProf. Maullu, Prof. PalmieriHow mechanised connective-tissue massage was re-designed around the microvacuole model, and what changes in the tissue response when stimulation is multi-alveolar.Source (PDF) ↗
- 06Scientific study 2019Prof. PalmieriTechnology description and evaluations of icoone®-H and the multi micro alveolar stimulation approach.Source (PDF) ↗
- 07i-Tech Industries technical brochure (2021)i-Tech IndustriesManufacturer technical documentation.Source (PDF) ↗
- 08icooneTalks Scientific Series — Dr. SorbelliniDr. SorbelliniicooneTalks scientific series — dermatology perspective.Source (PDF) ↗
- 09icooneTalks Scientific Series — Prof. SagginiProf. SagginiicooneTalks scientific series — physical medicine perspective.Source (PDF) ↗
- 10icooneTalks Scientific Series — Jocelyne RollandJ. Rolland, physiotherapisticooneTalks scientific series — physiotherapy practice perspective.Source (PDF) ↗
- 11Scientific Meeting proceedings Ii-Tech Scientific CommitteeProceedings of the i-Tech scientific meeting.Source (PDF) ↗
- 12Scientific Meeting proceedings IIi-Tech Scientific CommitteeProceedings of the i-Tech scientific meeting.Source (PDF) ↗
- 13Scientific Meeting proceedings IIIi-Tech Scientific CommitteeProceedings of the i-Tech scientific meeting.Source (PDF) ↗
Two further papers on clinical settings are listed on the Medical page. The manufacturer’s full science archive: icoone.com/science ↗.
Results archive
Before and after, documented by the manufacturer
More cases in the Results Book (PDF) and on the icoone® overview. Results vary; photography courtesy of i-Tech Industries.
Questions buyers ask
What is Multi Micro Alveolar Stimulation?
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i-Tech’s name for what the Roboderm® roller does: hundreds of small independent micro-stimulations per second across the skin surface — up to 21,600 a minute — instead of one large suction fold. It is designed around the microvacuole model of the subcutaneous tissue described by Prof. Jean-Claude Guimberteau.
Who reviews the science?
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i-Tech Industries maintains a scientific committee of 40+ physicians, surgeons, physiotherapists and researchers who evaluate protocols and publish the papers listed on this page. Proceedings of three scientific meetings are included below.
Are these studies FDA clearances?
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No. The FDA clearances are 510(k) K182453 (Laser Beauty) and K211272 (Laser-Med) for four labeled indications. The studies are the manufacturer’s and its collaborators’ evaluations of the technology and its programs; they are published by i-Tech and hosted here for due diligence.
Can I read the documents without leaving this site?
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Yes. The brochures, protocol cards and results book are hosted on dnadistribution.us. The peer papers open from icoone.com, the manufacturer’s archive, in a new tab.
Where is the medical documentation?
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On the icoone® Medical page, which carries the manufacturer’s physiotherapy, surgical and other medical programme documentation with the scope note that applies in the U.S.
Regulatory scope
FDA-cleared wording on this site applies only to the laser-equipped icoone® configurations — icoone® Laser Beauty (510(k) K182453) and icoone® Laser-Med (510(k) K211272) — and only to their four labeled indications: relief of minor muscle aches and pain; relief of muscle spasms; temporary improvement of local blood circulation; temporary reduction in the appearance of cellulite. Non-laser icoone® configurations and icoone® Microfacial are not represented as FDA-cleared.
icoone® is a registered trademark of I-Tech Industries S.r.l. Outcome figures cited by the manufacturer come from i-Tech clinical evaluations; individual results vary. Any business, pricing or revenue examples are illustrative only.
Revenue and ROI figures shown on this site are illustrative estimates based on assumptions you select. They are not guarantees, projections, or promises of earnings. Actual results depend on your market, pricing, operations, and business practices.